Chlorthalidone Impurity G
- Product Name
- Chlorthalidone Impurity G
- CAS No.
- 16289-13-7
- Chemical Name
- Chlorthalidone Impurity G
- Synonyms
- Chloro Chlorthalidone;Chlorthalidone Impurity G;Chlorthalidone EP Impurity G;Chlortalidone EP Impurity G;Chlortalidone (Chlorthalidone) EP Impurity G;3-(3,4-Dichlorophenyl)-3-hydroxy-phthalimidin;(3-(3,4-Dichlorophenyl)-3-hydroxy-phthalimidine);3-(3,4-Dichlorophenyl)-3-hydroxyisoindolin-1-one;3-(3,4-dichlorophenyl)-3-hydroxy-2H-isoindol-1-one;Chlortalidone Impurity 7（Chlortalidone EP Impurity G）
- CBNumber
- CB21176203
- Molecular Formula
- C14H9Cl2NO2
- Formula Weight
- 294.13
- MOL File
- 16289-13-7.mol
Chlorthalidone Impurity G Property
- Melting point:
- 197-2010C
- storage temp.
- -20°C Freezer
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White
- CAS DataBase Reference
- 16289-13-7
N-Bromosuccinimide Price
- Product number
- 22574
- Product name
- Chlorthalidone Impurity G
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 22574
- Product name
- Chlorthalidone Impurity G
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $51
- Updated
- 2023/01/06
- Product number
- 22574
- Product name
- Chlorthalidone Impurity G
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $146
- Updated
- 2024/03/01
- Product number
- C427520
- Product name
- ChloroChlorthalidone
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- IC20415
- Product name
- Chlorthalidone impurity G
- Packaging
- 2mg
- Price
- $200
- Updated
- 2021/12/16
Chlorthalidone Impurity G Chemical Properties,Usage,Production
Description
Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM), which may mediate its sustained vasodilatory activity. Dietary administration of chlorthalidone (8 mg per animal per day) reduces arterial hypertension and prevents or reduces ventricular hypertrophy in DOCA-salt hypertensive rats. Formulations containing chlorthalidone have been used alone or in combination with other antihypertensive agents to lower arterial blood pressure and as adjuvants to address edema caused by cardiac or renal disorders.
Chemical Properties
White Solid
Uses
Chlorthalidone impurity. Antihypertensive agent.